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Mutation of Phosphotransacetylase but Not Isocitrate Lyase Reduces the Virulence of Salmonella enterica Serovar Typhimurium in Mice

Yang Re Kim,^1, Shaun R. Brinsmade,² Zheng Yang,¹ Jorge Escalante-Semerena,² and Joshua Fierer^1,3*

VA Healthcare, San Diego, California,¹ Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin and,² Department of Medicine, University of California at San Diego School of Medicine, San Diego, California³

Received 21 June 2005/ Returned for modification 21 July 2005/ Accepted 10 January 2006

A phosphotransacetylase (pta) mutant of Salmonella enterica serovar Typhimurium was attenuated in mice but survived normally in macrophages. Complementation of the pta mutation in trans restored virulence. An isocitrate lyase (aceA) mutant was virulent, so the inability to use acetate as a sole carbon source does not explain the phenotype.

Editor: F. C. Fang

Present address: Kangman St. Mary’s Hospital, Seoul, South Korea.