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Infection and Immunity, May 2006, p. 2562-2567, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.2562-2567.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Bacterial Sinusitis and Otitis Media following Influenza Virus Infection in Ferrets

Ville T. Peltola,1 Kelli L. Boyd,2 Julie L. McAuley,1 Jerold E. Rehg,3 and Jonathan A. McCullers1*

Departments of Infectious Diseases,1 Pathology,3 Animal Resources Center, St. Jude Children's Research Hospital, Memphis, Tennessee2

Received 17 August 2005/ Returned for modification 27 September 2005/ Accepted 1 February 2006

Streptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia. Many of these infections result from antecedent influenza virus infections. In this study we sought to determine whether the frequency and character of secondary pneumococcal infections differed depending on the strain of influenza virus that preceded bacterial challenge. In young ferrets infected with influenza virus and then challenged with pneumococcus, influenza viruses of any subtype increased bacterial colonization of the nasopharynx. Nine out of 10 ferrets infected with H3N2 subtype influenza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected with either an H1N1 influenza A virus or an influenza B virus did so. These data may partially explain why bacterial complication rates are higher during seasons when H3N2 viruses predominate. This animal model will be useful for further study of the mechanisms that underlie viral-bacterial synergism.

* Corresponding author. Mailing address: Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794. Phone: (901) 495-3486. Fax: (901) 495-3099. E-mail: jon.mccullers{at}stjude.org.

Editor: J. N. Weiser

Infection and Immunity, May 2006, p. 2562-2567, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.2562-2567.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Duez, J.-M., Sixt, N., Pechinot, A. (2009). Influenza virus infection: don't forget the role of the mucociliary system!. J Antimicrob Chemother 63: 421-422 [Full Text]  
  • Zhang, H. (2008). Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza. J Antimicrob Chemother 62: 219-223 [Abstract] [Full Text]  
  • McCullers, J. A. (2006). Insights into the Interaction between Influenza Virus and Pneumococcus. Clin. Microbiol. Rev. 19: 571-582 [Abstract] [Full Text]  


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