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Infection and Immunity, May 2006, p. 3006-3011, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3006-3011.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The hbhA Gene of Mycobacterium tuberculosis Is Specifically Upregulated in the Lungs but Not in the Spleens of Aerogenically Infected Mice

Giovanni Delogu,1* Maurizio Sanguinetti,1 Brunella Posteraro,1 Stefano Rocca,2 Stefania Zanetti,3 and Giovanni Fadda1

Institute of Microbiology, Catholic University of the Sacred Hearth, Rome, Italy,1 Institute of General Pathology, Pathological Anatomy and Veterinary Obstetrics-Surgery Clinic,2 Department of Biomedical Sciences, University of Sassari, Sassari, Italy3

Received 19 September 2005/ Returned for modification 9 November 2005/ Accepted 25 January 2006

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

* Corresponding author. Mailing address: Institute of Microbiology, Catholic University of the Sacred Hearth, Largo Gemelli 8, 00168 Rome, Italy. Phone: 39 06 30154964. Fax: 39 06 3051152. E-mail: gdelogu{at}rm.unicatt.it.

Editor: J. L. Flynn

Infection and Immunity, May 2006, p. 3006-3011, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3006-3011.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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