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Infection and Immunity, May 2006, p. 3016-3020, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3016-3020.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice{dagger}

Nikhat Parveen,1* Kenneth A. Cornell,2 James L. Bono,3,{ddagger} Christen Chamberland,4 Patricia Rosa,3 and John M. Leong4

Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, ICPH Building, Newark, New Jersey 07103-2714,1 Department of Chemistry, Boise State University, 1910 University Drive, Boise, Idaho 83725-1520,2 Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840,3 Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 016554

Received 8 February 2006/ Accepted 16 February 2006

Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, ICPH Building, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103-2714. Phone: (973) 972-4483, ext. 25218. Fax: (973) 972-8981. E-mail: Parveeni{at}umdnj.edu.

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Editor: J. T. Barbieri

{ddagger} Present address: U.S. Meat Animal Research Center, Agricultural Research Service, U.S. Department of Agriculture, Clay Center, NE 68933-0166.

Infection and Immunity, May 2006, p. 3016-3020, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3016-3020.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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