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Infection and Immunity, May 2006, p. 3027-3029, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3027-3029.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Infectivity in the Mouse Model of Lung Infection

Lee Ann Campbell,* Amy Lee, and Cho-chou Kuo

Department of Pathobiology, University of Washington, Seattle, Washington

Received 27 October 2005/ Returned for modification 21 November 2005/ Accepted 1 February 2006

Previous studies determined that the Chlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism with N-glycanase decreases or ablates infectivity in vivo.

* Corresponding author. Mailing address: Department of Pathobiology, University of Washington, Box 357238, Seattle, WA 98195. Phone: (206) 543-0317. Fax: (206) 543-3873. E-mail: lacamp{at}u.washington.edu.

Editor: J. T. Barbieri

Infection and Immunity, May 2006, p. 3027-3029, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3027-3029.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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