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Infection and Immunity, May 2006, p. 3046-3051, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3046-3051.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Multiple Chromosomal Loci for the babA Gene in Helicobacter pylori

Ewa E. Hennig,1 Johnna M. Allen,2 and Timothy L. Cover2,3,4*

Department of Gastroenterology, Medical Center for Postgraduate Education, Cancer Center, 02-781 Warsaw, Poland,1 Departments of Medicine,2 Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232,3 VA Medical Center, Nashville, Tennessee 372124

Received 4 October 2005/ Returned for modification 16 November 2005/ Accepted 7 February 2006

Helicobacter pylori babA encodes an outer membrane protein that binds to fucosylated Lewis b blood group antigen. We analyzed a panel of 35 H. pylori strains and identified three possible chromosomal loci for babA. There was a significant association between the presence of babA and the presence of cagA (P = 0.0001). Phylogenetic analysis of babA alleles revealed two divergent families of signal sequences. Among 17 strains in which an intact in-frame babA allele was identified, 10 expressed a detectable BabA protein. Expression of a BabA protein and the Lewis b-binding phenotype were not dependent on the chromosomal locus of babA. These data indicate that there is marked heterogeneity among H. pylori strains in babA genetic content and BabA expression.

* Corresponding author. Mailing address: Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232. Phone: (615) 322-2035. Fax: (615) 343-6160. E-mail: timothy.L.cover{at}vanderbilt.edu.

Editor: J. B. Bliska

Infection and Immunity, May 2006, p. 3046-3051, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3046-3051.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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