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Infection and Immunity, May 2006, p. 3060-3064, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3060-3064.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of the Histone-Like Nucleoid Structuring Protein in Colonization, Motility, and Bile-Dependent Repression of Virulence Gene Expression in Vibrio cholerae

Amalendu Ghosh, Kalidas Paul, and Rukhsana Chowdhury*

Biophysics Division, Indian Institute of Chemical Biology, Calcutta 700 032, India

Received 28 December 2005/ Returned for modification 23 January 2006/ Accepted 1 February 2006

Bile-mediated repression of virulence gene expression is relieved in a Vibrio cholerae hns mutant. The mutant also exhibited reduced motility due to lower flrA expression, higher in vivo production of the virulence factors, and lower colonization efficiency. The colonization defect of the mutant was due to low FlrA production.

* Corresponding author. Mailing address: Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Calcutta 700 032, India. Phone: 91 33 473 0350. Fax: 91 33 473 5197. E-mail: rukhsana{at}iicb.res.in.

Editor: J. T. Barbieri

Infection and Immunity, May 2006, p. 3060-3064, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3060-3064.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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