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Infection and Immunity, May 2006, p. 3065-3067, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3065-3067.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica

Sabine Chlosta,1,3 Douglas S. Fishman,2,4 Lynne Harrington,1 Erin E. Johnson,2 Mitchell D. Knutson,5 Marianne Wessling-Resnick,2 and Bobby J. Cherayil1*

Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts;,1 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts,2 Department of Medical Microbiology and Immunology of Infection, Charité Medical School, Berlin, Germany,3 Division of Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts,4 Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida5

Received 7 December 2005/ Returned for modification 31 January 2006/ Accepted 15 February 2006

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

* Corresponding author. Mailing address: Pediatric Gastroenterology Unit, Massachusetts General Hospital, Building 114, 16th Street, Charlestown, MA 02129. Phone: (617) 726-4170. Fax: (617) 726-4172. E-mail: cherayil{at}helix.mgh.harvard.edu.

Editor: F. C. Fang

Infection and Immunity, May 2006, p. 3065-3067, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3065-3067.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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