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Infection and Immunity, May 2006, p. 3068-3070, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3068-3070.2006

Administration of Antibody to the Lung Protects Mice against Pneumonic Plague

Jim Hill,* Jim E. Eyles, Stephen J. Elvin, Gareth D. Healey, Roman A. Lukaszewski, and Richard W. Titball

Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom

Received 1 February 2006/ Accepted 8 February 2006

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

* Corresponding author. Mailing address: Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom. Phone: 44 1980 614 756. Fax: 44 1980 614 307. E-mail: jhill{at}dstl.gov.uk.

Editor: J. B. Bliska

Infection and Immunity, May 2006, p. 3068-3070, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3068-3070.2006




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