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Infection and Immunity, June 2006, p. 3342-3346, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.00169-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Bile Acids Enhance Invasiveness of Cryptosporidium spp. into Cultured Cells

Hanping Feng, Weijia Nie, Abhineet Sheoran, Quanshun Zhang, and Saul Tzipori*

Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts

Received 31 January 2006/ Returned for modification 8 March 2006/ Accepted 15 March 2006

Bile salts such as sodium taurocholate (NaTC) are routinely used to induce the excystation of Cryptosporidium oocysts. Here we show that NaTC significantly enhanced the invasion of several cultured cell lines by freshly excysted Cryptosporidium parvum and Cryptosporidium hominis sporozoites. A variety of purified bile salts or total bile from bovine also enhanced the invasion of cultured cells by C. parvum. Further studies demonstrated that NaTC increased protein secretion and gliding motility of sporozoites, the key processes for successful invasion. These observations may lead to improved Cryptosporidium infectivity of cultured cells and help future studies on the host-parasite interaction.

* Corresponding author. Mailing address: Division of Infectious Diseases, Tufts University Cummings School of Veterinary Medicine, 200 Westborough Road, North Grafton, MA 01536. Phone: (508) 839-7955. Fax: (508) 839-7911. E-mail: saul.tzipori{at}tufts.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, June 2006, p. 3342-3346, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.00169-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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