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Infection and Immunity, June 2006, p. 3657-3662, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.02030-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Toll-Like Receptor 2 Is Required for Control of Pulmonary Infection with Francisella tularensis

Meenakshi Malik, Chandra Shekhar Bakshi, Bikash Sahay, Aaloki Shah, Steven A. Lotz, and Timothy J. Sellati*

Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208

Received 16 December 2005/ Returned for modification 18 January 2006/ Accepted 11 March 2006

Toll-like receptor 2 (TLR2) deficiency enhances murine susceptibility to infection by Francisella tularensis as indicated by accelerated mortality, higher bacterial burden, and greater histopathology. Analysis of pulmonary cytokine levels revealed that TLR2 deficiency results in significantly lower levels of tumor necrosis factor alpha and interleukin-6 but increased amounts of gamma interferon and monocyte chemoattractant protein 1. This pattern of cytokine production may contribute to the exaggerated pathogenesis seen in TLR2–/– mice. Collectively, these findings suggest that TLR2 plays an important role in tempering the host response to pneumonic tularemia.

* Corresponding author. Mailing address: Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, MC151, ME205B, Albany, NY 12208-3479. Phone: (518) 262-8140. Fax: (518) 262-2885. E-mail: sellatt{at}mail.amc.edu.

Editor: J. B. Bliska

Infection and Immunity, June 2006, p. 3657-3662, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.02030-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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