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Infection and Immunity, June 2006, p. 3668-3672, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.00196-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Constitutive Differences in Gene Expression Profiles Parallel Genetic Patterns of Susceptibility to Tuberculosis in Mice^¶

Marianna O. Orlova,^1,2 Konstantin B. Majorov,¹ Irina V. Lyadova,¹ Eugenii B. Eruslanov,^1, Cyr E. M'lan,^3, Celia M. T. Greenwood,³ Erwin Schurr,^2, and Alexander S. Apt^1,*

Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza Alley 2, Moscow 107564, Russia,¹ McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, H3G 1A4 Quebec, Canada,² Program in Genetics and Genomic Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada³

Received 3 February 2006/ Returned for modification 8 March 2006/ Accepted 16 March 2006

Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice.

^¶ Supplemental material for this article may be found at http://iai.asm.org/.

Editor: A. D. O'Brien

Present address: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115.

Present address: Department of Statistics, University of Connecticut, Storrs, CT 06269.

Joint senior authors.

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