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Infection and Immunity, June 2006, p. 3673-3677, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.02013-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Localization of the C3-Like ADP-Ribosyltransferase from Staphylococcus aureus during Bacterial Invasion of Mammalian Cells

Gabriella Molinari,1 Manfred Rohde,1 Christian Wilde,3 Ingo Just,2 Klaus Aktories,3 and Gursharan S. Chhatwal1*

Department of Microbial Pathogenesis, GBF—German Research Centre for Biotechnology, Braunschweig, Germany,1 Institut für Toxikologie der Medizinischen Hochschule Hannover, Hannover, Germany,2 Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Freiburg, Germany3

Received 14 December 2005/ Returned for modification 21 January 2006/ Accepted 17 March 2006

The C3stau2 exoenzyme from Staphylococcus aureus is a C3-like ADP-ribosyltransferase which possesses no specific receptor-binding domain or translocation unit required for entry in target cells where its substrate is located. Here we show that C3stau2 can reach its target after invasion of staphylococci in eukaryotic cells without needing translocation.

* Corresponding author. Mailing address: Department of Microbial Pathogenesis, GBF—German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany. Phone: 49 531 6181 297. Fax: 49 531 6181 708. E-mail: gsc{at}gbf.de.

Editor: J. T. Barbieri

Infection and Immunity, June 2006, p. 3673-3677, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.02013-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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