This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scheel, O.
Right arrow Articles by Schromm, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scheel, O.
Right arrow Articles by Schromm, A. B.

 Previous Article  |  Next Article 

Infection and Immunity, July 2006, p. 4354-4356, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.01783-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cell Activation by Ligands of the Toll-Like Receptor and Interleukin-1 Receptor Family Depends on the Function of the Large-Conductance Potassium Channel MaxiK in Human Macrophages

Olaf Scheel,1 Martin Papavlassopoulos,1 Rikard Blunck,2 Andreas Gebert,3 Thomas Hartung,4 Ulrich Zähringer,1 Ulrich Seydel,1* and Andra B. Schromm1

Department of Immunochemistry and Biochemical Microbiology, Research Center Borstel-Center for Medicine and Biosciences, 23845 Borstel,1 Institute of Anatomy, University of Lübeck, 23538 Lübeck,3 Department of Biochemical Pharmacology, University of Constance, 78457 Constance, Germany,4 Department of Physiology, David Geffen School of Medicine at University of California—Los Angeles, Los Angeles, California 900952

Received 3 November 2005/ Returned for modification 22 December 2005/ Accepted 18 March 2006

Performing patch-clamp experiments on human macrophages, we show that the K+ channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.

* Corresponding author. Mailing address: Research Center Borstel, Department of Immunochemistry and Biochemical Microbiology, Division of Biophysics, Parkallee 10, 23845 Borstel, Germany. Phone: 49 04537-188232. Fax: 49 04537-188632. E-mail: useydel{at}fz-borstel.de.

Editor: J. T. Barbieri

Infection and Immunity, July 2006, p. 4354-4356, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.01783-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Illek, B., Fu, Z., Schwarzer, C., Banzon, T., Jalickee, S., Miller, S. S., Machen, T. E. (2008). Flagellin-stimulated Cl- secretion and innate immune responses in airway epithelia: role for p38. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L531-L542 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»