IAI Track the topics, authors and articles important to you
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mildiner-Earley, S.
Right arrow Articles by Miller, V. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mildiner-Earley, S.
Right arrow Articles by Miller, V. L.
Infection and Immunity, July 2006, p. 4361-4365, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00154-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Characterization of a Novel Porin Involved in Systemic Yersinia enterocolitica Infection

Shirly Mildiner-Earley1 and Virginia L. Miller1,2*

Departments of Molecular Microbiology,1 Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 631102

Received 30 January 2006/ Returned for modification 15 March 2006/ Accepted 10 April 2006

Yersinia enterocolitica is an enteric pathogen capable of causing systemic disease in a murine model. We have identified a novel protein, systemic factor protein A (SfpA), conserved in other pathogenic bacteria that is involved in systemic disease. Analysis of bacterial colonization revealed that a {Delta}sfpA strain is defective in mesenteric lymph node colonization. Bioinformatics and functional studies suggest that SfpA is a porin.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 286-2891. Fax: (314) 286-2896. E-mail: Virginia{at}borcim.wustl.edu.

Editor: J. B. Bliska

Infection and Immunity, July 2006, p. 4361-4365, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00154-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2006 by the American Society for Microbiology. All rights reserved.