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Infection and Immunity, July 2006, p. 4361-4365, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00154-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Characterization of a Novel Porin Involved in Systemic Yersinia enterocolitica Infection

Shirly Mildiner-Earley1 and Virginia L. Miller1,2*

Departments of Molecular Microbiology,1 Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 631102

Received 30 January 2006/ Returned for modification 15 March 2006/ Accepted 10 April 2006

Yersinia enterocolitica is an enteric pathogen capable of causing systemic disease in a murine model. We have identified a novel protein, systemic factor protein A (SfpA), conserved in other pathogenic bacteria that is involved in systemic disease. Analysis of bacterial colonization revealed that a {Delta}sfpA strain is defective in mesenteric lymph node colonization. Bioinformatics and functional studies suggest that SfpA is a porin.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 286-2891. Fax: (314) 286-2896. E-mail: Virginia{at}borcim.wustl.edu.

Editor: J. B. Bliska

Infection and Immunity, July 2006, p. 4361-4365, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00154-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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