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Infection and Immunity, July 2006, p. 4366-4369, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00142-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain

Teresa Bader,1 Klaus Schröppel,2 Stefan Bentink,1 Nina Agabian,3 Gerwald Köhler,3 and Joachim Morschhäuser1*

Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg,1 Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universität Erlangen, Wasserturmstraße 3, D-91054 Erlangen, Germany,2 Department of Cell and Tissue Biology, University of California, San Francisco, 521 Parnassus, San Francisco, California 941433

Received 27 January 2006/ Returned for modification 18 March 2006/ Accepted 6 April 2006

By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.

* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany. Phone: 49-931-31 21 52. Fax: 49-931-31 25 78. E-mail: joachim.morschhaeuser{at}mail.uni-wuerzburg.de.

Editor: A. Casadevall

Infection and Immunity, July 2006, p. 4366-4369, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00142-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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