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Infection and Immunity, July 2006, p. 4379-4382, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00195-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of Tumor Necrosis Factor Alpha in Development of Immunity against Cryptosporidium parvum Infection

I-Sarah Lean,1 Sonia Lacroix-Lamandé,2 Fabrice Laurent,2 and Vincent McDonald1*

Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Turner Street, London E1 2AD, United Kingdom,1 Laboratoire Contrôle et Immunologie des Maladies Entériques du Nouveau-né, UR1282, IASP213, IFR136, INRA de Tours, 37380 Nouzilly, France2

Received 3 February 2006/ Returned for modification 12 March 2006/ Accepted 12 April 2006

Tumor necrosis factor (TNF-{alpha}) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-{alpha}-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-{alpha} might have only a redundant role for establishing immunity against C. parvum.

* Corresponding author. Mailing address: Barts and the London School of Medicine, Institute of Cell and Molecular Science, Centre for Gastroenterology, Turner Street, London E1 2AD, United Kingdom. Phone: (44) 20 7882 7202. Fax: (44) 20 7882 2192. E-mail: v.mcdonald{at}qmul.ac.uk.

Editor: W. A. Petri, Jr.

Infection and Immunity, July 2006, p. 4379-4382, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00195-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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