This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marion, R.
Right arrow Articles by Favennec, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marion, R.
Right arrow Articles by Favennec, L.

 Previous Article

Infection and Immunity, July 2006, p. 4387-4389, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.02055-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Transient Neonatal Cryptosporidium parvum Infection Triggers Long-Term Jejunal Hypersensitivity to Distension in Immunocompetent Rats

Rachel Marion,1,{dagger} Asiya Baishanbo,1,2,{dagger} Gilles Gargala,1 Arnaud François,3 Philippe Ducrotté,1 Celia Duclos,3 Jean Fioramonti,4 Jean Jacques Ballet,5 and Loïc Favennec1*

Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 76031 Rouen, France,1 College of Pharmacy, Xinjiang Medical University, Urumqi, China,2 Laboratoire d'Histopathologie, CHU Charles Nicolle, Rouen, France,3 INRA, 180 Chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France,4 Laboratoire d'Immunologie et Immunopathologie, UPRES EA-2128, CHU Clemenceau, Caen, France5

Received 21 December 2005/ Returned for modification 30 January 2006/ Accepted 4 April 2006

In 5-day-old immunocompetent Sprague-Dawley rats infected with either 102 or 105 Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.

* Corresponding author. Mailing address: Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen, France. Phone: 33 (0)2 32 88 66 39. Fax: 33 (0)2 32 88 68 75. E-mail: loic.favennec{at}univ-rouen.fr.

Editor: W. A. Petri, Jr.

{dagger} Both authors contributed equally to the work.

Infection and Immunity, July 2006, p. 4387-4389, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.02055-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Khaldi, S., Gargala, G., Le Goff, L., Parey, S., Francois, A., Fioramonti, J., Ballet, J.-J., Dupont, J.-P., Ducrotte, P., Favennec, L. (2009). Cryptosporidium parvum Isolate-Dependent Postinfectious Jejunal Hypersensitivity and Mast Cell Accumulation in an Immunocompetent Rat Model. Infect. Immun. 77: 5163-5169 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»