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Infection and Immunity, August 2006, p. 4694-4707, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00210-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Unique Features of a Highly Pathogenic Campylobacter jejuni Strain{dagger}

Dirk Hofreuter,1 Jennifer Tsai,2 Robert O. Watson,1 Veronica Novik,1 Bill Altman,2 Michelle Benitez,2 Christina Clark,2 Clotilde Perbost,2 Thomas Jarvie,2 Lei Du,2 and Jorge E. Galán1*

Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536,1 454 Life Sciences, Branford, Connecticut 064052

Received 6 February 2006/ Returned for modification 4 April 2006/ Accepted 11 May 2006

Campylobacter jejuni, a major human enteric pathogen, exhibits significant strain-to-strain differences which result in differences in pathogenic potential. C. jejuni 81-176 is a highly virulent strain that exhibits unique pathogenic features and is used by many research laboratories. We have determined the nucleotide sequence of its genome and compared it to the genomes of other sequenced C. jejuni strains. We identified a number of unique genetic features which may confer specific metabolic and pathogenic properties on this strain. We have also identified regions of the C. jejuni genome that are hot spots for the integration of horizontally acquired genetic material. This information should help the understanding of the pathogenesis of C. jejuni and, in particular, the unique features of this highly pathogenic strain.

* Corresponding author. Mailing address: Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, CT 06536. Phone: (203) 737-2404. Fax: (203) 737-2630. E-mail: jorge.galan{at}yale.edu.

{dagger} Supplemental material for this article may by found at http://iai.asm.org/.

Editor: J. B. Bliska

Infection and Immunity, August 2006, p. 4694-4707, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00210-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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