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Infection and Immunity, August 2006, p. 4910-4914, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.01860-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immunogenicity and Protective Immunity against Bubonic Plague and Pneumonic Plague by Immunization of Mice with the Recombinant V10 Antigen, a Variant of LcrV

Kristin L. DeBord,1 Deborah M. Anderson,1 Melanie M. Marketon,1 Katie A. Overheim,1 R. William DePaolo,2 Nancy A. Ciletti,1 Bana Jabri,2 and Olaf Schneewind1*

Department of Microbiology,1 Department of Pathology, University of Chicago, Chicago, Illinois 606372

Received 14 November 2005/ Returned for modification 27 January 2006/ Accepted 24 April 2006

In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.

* Corresponding author. Mailing address: Department of Microbiology, University of Chicago, 920 E. 58th Street, Chicago, IL 60637. Phone: (773) 834-9060. Fax: (773) 834-8150. E-mail: oschnee{at}bsd.uchicago.edu.

Editor: V. J. DiRita

Infection and Immunity, August 2006, p. 4910-4914, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.01860-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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