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Infection and Immunity, August 2006, p. 4918-4921, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00258-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The yjeQ Gene Is Required for Virulence of Staphylococcus aureus

Tracey L. Campbell,1 James Henderson,2 David E. Heinrichs,2 and Eric D. Brown1*

Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5,1 Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C12

Received 16 February 2006/ Returned for modification 27 April 2006/ Accepted 9 May 2006

Gene products required for in vivo growth and survival of Staphylococcus aureus and other pathogens represent new targets for antimicrobial chemotherapy. In this study we created a Staphylococcus aureus yjeQ deletion strain and tested its virulence using a mouse kidney abscess infection model. The yjeQ deletion strain was compromised for growth in vitro and severely attenuated for virulence. We concluded that yjeQ is an attractive and novel new drug target.

* Corresponding author. Mailing address: Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5. Phone: (905) 525-9140, ext. 22392. Fax: (905) 522-9033. E-mail: ebrown{at}mcmaster.ca.

Editor: V. J. DiRita

Infection and Immunity, August 2006, p. 4918-4921, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00258-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Campbell, T. L., Brown, E. D. (2008). Genetic Interaction Screens with Ordered Overexpression and Deletion Clone Sets Implicate the Escherichia coli GTPase YjeQ in Late Ribosome Biogenesis. J. Bacteriol. 190: 2537-2545 [Abstract] [Full Text]  
  • Tu Quoc, P. H., Genevaux, P., Pajunen, M., Savilahti, H., Georgopoulos, C., Schrenzel, J., Kelley, W. L. (2007). Isolation and Characterization of Biofilm Formation-Defective Mutants of Staphylococcus aureus. Infect. Immun. 75: 1079-1088 [Abstract] [Full Text]  


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