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Interleukin-10 Inhibits Gram-Negative-Microbe-Specific Human Receptor Activator of NF-B Ligand-Positive CD4⁺-Th1-Cell- Associated Alveolar Bone Loss In Vivo

Laboratory of Molecular Microbial Immunity and Division of Periodontology, Eastman Department of Dentistry and Centre for Oral Biology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620

Received 26 March 2006/ Returned for modification 2 May 2006/ Accepted 5 May 2006

To study anti-inflammatory cytokine effects on RANKL⁺-T-cell-mediated osteoclastogenesis in vivo, we injected human interleukin-10 (hIL-10) into pathogen-infected HuPBL-NOD/SCID mice. The results show significantly decreased RANKL⁺ Th1-associated alveolar bone loss and coexpression of human gamma interferon (hIFN-) and human macrophage colony-stimulating factor, but not hIL-4, in RANKL⁺ Th cells compatible with those from successfully treated aggressive periodontitis subjects. Thus, there are critical cytokine interactions linking hIFN-⁺ Th1 cells to RANKL-RANK/OPG signaling for periodontal osteoclastogenesis in vivo.

Editor: J. B. Bliska

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