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Infection and Immunity, August 2006, p. 4932-4938, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00442-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mapping of B-Cell Epitopes on a Novel 11.5-Kilodalton Fasciola hepatica-Schistosoma mansoni Cross-Reactive Antigen Belonging to a Member of the F. hepatica Saposin-Like Protein Family

Daricel Torres and Ana M. Espino*

Laboratory of Molecular Parasitology and Immunology, Department of Microbiology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico

Received 17 March 2006/ Returned for modification 14 April 2006/ Accepted 13 May 2006

FhSAP-2 is a novel member of the Fasciola hepatica saposin-like protein family that induces protection in rabbits against a challenge infection. We investigated the presence of lineal B-cell epitopes within this protein using a set of overlapping synthetic peptides. Peptides were tested in enzyme-linked immunosorbent assays against sera from rabbits infected with F. hepatica. Two dominant epitopes were identified, which were also highly reactive with sera from mice infected with Schistosoma mansoni. These peptides may be suitable to incorporate into a polyepitope-based vaccine formulation against F. hepatica.

* Corresponding author. Mailing Address: Department of Microbiology, Laboratory of Molecular Parasitology and Immunology, University of Puerto Rico, School of Medicine, Office A-302, P.O. Box 365067, San Juan, PR 00936-5067. Phone: (787) 758-2525, ext. 1318. Fax: (787) 758-4808. E-mail: aespino{at}rcm.upr.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, August 2006, p. 4932-4938, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00442-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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