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Infection and Immunity, August 2006, p. 4950-4953, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00204-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress

Alexandra Clauditz,1 Alexandra Resch,1 Karsten-Peter Wieland,1 Andreas Peschel,2 and Friedrich Götz1*

Mikrobielle Genetik, Universität Tübingen, Tübingen, Germany,1 Medizinische Mikrobiologie, Universität Tübingen, Tübingen, Germany2

Received 5 February 2006/ Returned for modification 10 May 2006/ Accepted 30 May 2006

Staphyloxanthin is a membrane-bound carotenoid of Staphylococcus aureus. Here we studied the interaction of staphyloxanthin with reactive oxygen substances (ROS) and showed by comparative analysis of the wild type (WT) and an isogenic crtM mutant that the WT is more resistant to hydrogen peroxide, superoxide radical, hydroxyl radical, hypochloride, and neutrophil killing.

* Corresponding author. Mailing address: Mikrobielle Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. Phone: (49) 7071 29746-36 or -35. Fax: (49) 7071 295039. E-mail: friedrich.goetz{at}uni-tuebingen.de.

Editor: F. C. Fang

Infection and Immunity, August 2006, p. 4950-4953, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00204-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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