This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCord, A. M.
Right arrow Articles by Anderson, B. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCord, A. M.
Right arrow Articles by Anderson, B. E.

 Previous Article  |  Next Article 

Infection and Immunity, September 2006, p. 5185-5190, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00622-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Autocrine Role for Interleukin-8 in Bartonella henselae-Induced Angiogenesis

Amy M. McCord, Sandra I. Resto-Ruiz, and Burt E. Anderson*

Department of Molecular Medicine, School of Basic Biomedical Science, College of Medicine, University of South Florida, Tampa, Florida 33612

Received 18 April 2006/ Returned for modification 2 May 2006/ Accepted 13 June 2006

The gram-negative bacterium Bartonella henselae is capable of causing angiogenic lesions as a result of infection. Previously, it has been shown that B. henselae infection can result in production of the chemokine interleukin-8 (IL-8). In this study, we demonstrated that monocytes, endothelial cells, and hepatocytes produce IL-8 in response to B. henselae infection. We also investigated the role of IL-8 in B. henselae-induced endothelial cell proliferation and capillary tube formation. Both in vitro angiogenesis assays were IL-8 dependent. B. henselae-mediated inhibition of apoptosis, as indicated by gene expression of Bax and Bcl-2, was also shown to be IL-8 dependent in endothelial cells. Furthermore, infection of endothelial cells with B. henselae stimulated upregulation of the IL-8 chemokine receptor CXCR2. Infection of human endothelial cells by B. henselae resulting in IL-8 production likely plays a central role in the ability of this organism to cause angiogenesis during infection.

* Corresponding author. Mailing address: Department of Molecular Medicine, School of Basic Biomedical Science, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC10, Tampa, FL 33612. Phone: (813) 974-2608. Fax: (813) 974-4151. E-mail: banderso{at}hsc.usf.edu.

Editor: J. T. Barbieri

Infection and Immunity, September 2006, p. 5185-5190, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00622-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gillaspie, D., Perkins, I., Larsen, K., McCord, A., Pangonis, S., Sweger, D., Seleem, M. N., Sriranganathan, N., Anderson, B. E. (2009). Plasmid-Based System for High-Level Gene Expression and Antisense Gene Knockdown in Bartonella henselae. Appl. Environ. Microbiol. 75: 5434-5436 [Abstract] [Full Text]  
  • Breitschwerdt, E. B., Maggi, R. G., Varanat, M., Linder, K. E., Weinberg, G. (2009). Isolation of Bartonella vinsonii subsp. berkhoffii Genotype II from a Boy with Epithelioid Hemangioendothelioma and a Dog with Hemangiopericytoma. J. Clin. Microbiol. 47: 1957-1960 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»