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Infection and Immunity, September 2006, p. 5402-5407, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00244-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparison of the Host Responses to Wild-Type and cpsB Mutant Klebsiella pneumoniae Infections

Matthew S. Lawlor,1 Scott A. Handley,1 and Virginia L. Miller1,2*

Departments of Molecular Microbiology,1 Pediatrics, Washington University School of Medicine, St. Louis, Missouri 631102

Received 14 February 2006/ Returned for modification 28 March 2006/ Accepted 14 June 2006

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Campus Box 8230, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 286-2891. Fax: (314) 286-2896. E-mail: virginia{at}borcim.wustl.edu.

Editor: J. B. Bliska

Infection and Immunity, September 2006, p. 5402-5407, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00244-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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