IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
IAI.00058-06v1
75/1/504    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rosas-Magallanes, V.
Right arrow Articles by Neyrolles, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rosas-Magallanes, V.
Right arrow Articles by Neyrolles, O.
Infection and Immunity, January 2007, p. 504-507, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.00058-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages{triangledown}

Vania Rosas-Magallanes,1 Gustavo Stadthagen-Gomez,1 Jean Rauzier,1 Luis B. Barreiro,1 Ludovic Tailleux,1 Frédéric Boudou,1 Ruth Griffin,2 Jérome Nigou,3 Mary Jackson,1 Brigitte Gicquel,1 and Olivier Neyrolles1,4*

Unit of Mycobacterial Genetics, Institut Pasteur, Paris, France,1 Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom,2 Department of Molecular Mechanisms of Mycobacterial Infections, Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, Toulouse, France,3 Centre National de la Recherche Scientifique URA 2172, Paris, France4

Received 11 January 2006/ Returned for modification 28 February 2006/ Accepted 26 September 2006

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

* Corresponding author. Mailing address: Institute Pasteur, Unit of Mycobacterial Genetics, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France. Phone: 33-1-45-68-88-40. Fax: 33-1-45-68-88-43. E-mail: neyrolle{at}pasteur.fr.

{triangledown} Published ahead of print on 9 October 2006.

Editor: J. L. Flynn

Infection and Immunity, January 2007, p. 504-507, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.00058-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2007 by the American Society for Microbiology. All rights reserved.