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Infection and Immunity, January 2007, p. 508-511, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.01202-06

Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis{triangledown}

J. Bozue,{dagger} C. K. Cote,{dagger} K. L. Moody, and S. L. Welkos*

Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702

Received 31 July 2006/ Returned for modification 16 September 2006/ Accepted 20 October 2006

The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.

* Corresponding author. Mailing address: Bacteriology Division, USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702. Phone: (301) 619-4930. Fax: (301) 619-2152. E-mail: susan.welkos{at}amedd.army.mil.

{triangledown} Published ahead of print on 30 October 2006.

Editor: J. L. Flynn

{dagger} These authors contributed equally to this work.

Infection and Immunity, January 2007, p. 508-511, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.01202-06




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