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Infection and Immunity, January 2007, p. 512-517, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.00756-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Absence of Toll-Like Receptor 4 Signaling Results in Delayed Yersinia enterocolitica YopP-Induced Cell Death of Dendritic Cells

Sabine Gröbner,^1,* Sebastian Schulz,^1, Irena Soldanova,¹ Dani S. J. Gunst,¹ Michaela Waibel,² Sebastian Wesselborg,² Stefan Borgmann,¹ and Ingo B. Autenrieth¹

Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tübingen, Tübingen, Germany,¹ Department of Internal Medicine I, Eberhard Karls University of Tübingen, Tübingen, Germany²

Received 12 May 2006/ Returned for modification 21 June 2006/ Accepted 12 October 2006

In an initial period (4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.

Published ahead of print on 30 October 2006.

Editor: J. B. Bliska

S.G. and S.S. contributed equally to this work.

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