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Infection and Immunity, January 2007, p. 518-522, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.01344-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Protein P200 Is Dispensable for Mycoplasma pneumoniae Hemadsorption but Not Gliding Motility or Colonization of Differentiated Bronchial Epithelium{triangledown}

Jarrat L. Jordan,1,{dagger} How-Yi Chang,1 Mitchell F. Balish,1,{ddagger} Lynley S. Holt,1 Stephanie R. Bose,1 Benjamin M. Hasselbring,1 Robert H. Waldo III,1,§ Thomas M. Krunkosky,2 and Duncan C. Krause1*

Department of Microbiology,1 Department of Anatomy and Radiology, University of Georgia, Athens, Georgia2

Received 21 August 2006/ Returned for modification 19 September 2006/ Accepted 6 October 2006

Mycoplasma pneumoniae protein P200 was localized to the terminal organelle, which functions in cytadherence and gliding motility. The loss of P200 had no impact on binding to erythrocytes and A549 cells but resulted in impaired gliding motility and colonization of differentiated bronchial epithelium. Thus, gliding may be necessary to overcome mucociliary clearance.

* Corresponding author. Mailing address: Department of Microbiology, 523 Biological Sciences Building, University of Georgia, Athens, GA 30602. Phone: (706) 542-2671. Fax: (706) 542-2674. E-mail: dkrause{at}uga.edu.

{triangledown} Published ahead of print on 16 October 2006.

Editor: D. L. Burns

{dagger} Present address: Centocor Research and Development, Inc., Radnor, PA.

{ddagger} Present address: Department of Microbiology, Miami University, Oxford, OH.

§ Present address: University of Tennessee Health Science Center, Memphis, TN.

Infection and Immunity, January 2007, p. 518-522, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.01344-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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