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Infection and Immunity, January 2007, p. 527-530, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.00732-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis{triangledown}

Wonder P. Drake,1* Mary S. Dhason,2 Michele Nadaf,1 Bryan E. Shepherd,3 Sangeetha Vadivelu,1 Rana Hajizadeh,1 Lee S. Newman,4,5 and Spyros A. Kalams1,6

Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee,1 Department of Biology, Texas A&M University, College Station, Texas,2 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee,3 Department of Preventive Medicine and Biometrics,4 Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado,5 Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee6

Received 5 May 2006/ Returned for modification 6 July 2006/ Accepted 20 October 2006

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD–) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.

* Corresponding author. Mailing address: Vanderbilt University School of Medicine, Division of Infectious Diseases, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232. Phone: (615) 322-2035. Fax: (615) 343-6160. E-mail: Wonder.drake{at}vanderbilt.edu.

{triangledown} Published ahead of print on 6 November 2006.

Editor: J. L. Flynn

Infection and Immunity, January 2007, p. 527-530, Vol. 75, No. 1
0019-9567/07/$08.00+0     doi:10.1128/IAI.00732-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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