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Infection and Immunity, October 2007, p. 4799-4803, Vol. 75, No. 10
0019-9567/07/$08.00+0     doi:10.1128/IAI.00738-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Rapid Elimination of Toxoplasma gondii by Gamma Interferon-Primed Mouse Macrophages Is Independent of CD40 Signaling{triangledown}

Yanlin Zhao, Douglas Wilson, Suzanne Matthews, and George S. Yap*

Department of Molecular Microbiology and Immunology, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02912

Received 31 May 2007/ Returned for modification 30 June 2007/ Accepted 24 July 2007

Autophagy has been implicated in the intracellular destruction of Toxoplasma gondii by primed macrophages following gamma interferon (IFN-{gamma}) activation of p47 GTPases. CD40 ligation has also been shown to trigger autophagic elimination of T. gondii independent of IFN-{gamma} and p47 GTPases. Here we demonstrate that IFN-{gamma}/p47 GTPase-dependent elimination of T. gondii by strain CPS vaccine-primed macrophages is independent of CD40/tumor necrosis factor signaling. Similar to wild-type controls, both CD40-deficient and tumor necrosis factor receptor 1/2 (TNFR1/2)-deficient macrophages can efficiently eliminate invaded strain GFP-PTG and restrain its replication following priming. In contrast, macrophages from mice lacking the IFN-{gamma} receptor gene neither clear the parasites nor repress their proliferation. Thus, CD40 and IFN-{gamma}-induced pathogen elimination might represent two independent resistance pathways, the latter of which plays a primary role in anti-Toxoplasma immunity in mice.

* Corresponding author. Mailing address: Box G-B6, Department of Molecular Microbiology and Immunology, Warren Alpert Medical School, Brown University, Providence, RI 02912. Phone: (401) 863-3483. Fax: (401) 863-1971. E-mail: george_yap{at}brown.edu

{triangledown} Published ahead of print on 6 August 2007.

Editor: W. A. Petri, Jr.

Infection and Immunity, October 2007, p. 4799-4803, Vol. 75, No. 10
0019-9567/07/$08.00+0     doi:10.1128/IAI.00738-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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Copyright © 2007 by the American Society for Microbiology. All rights reserved.