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 Previous Article

Infection and Immunity, October 2007, p. 5068-5072, Vol. 75, No. 10
0019-9567/07/$08.00+0     doi:10.1128/IAI.00287-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Interleukin 18 Participates in the Early Inflammatory Response and Bacterial Clearance during Pneumonia Caused by Nontypeable Haemophilus influenzae{triangledown}

Catharina W. Wieland,1,2* Sandrine Florquin,3 and Tom van der Poll1,2

Center of Infection and Immunity Amsterdam (CINIMA),1 Center of Experimental and Molecular Medicine (CEMM),2 Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands3

Received 21 February 2007/ Returned for modification 25 April 2007/ Accepted 17 July 2007

Nontypeable Haemophilus influenzae (NTHi) is a common gram-negative respiratory pathogen. To determine the role of the proinflammatory cytokine interleukin 18 (IL-18) during NTHi pneumonia, normal wild-type (WT) and IL-18 knockout (KO) mice were intranasally infected with NTHi. IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. These data identify IL-18 as part of an adequate innate immune response during NTHi pneumonia.

* Corresponding author. Mailing address: Center of Infection and Immunity, G2-132, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5666034. Fax: 31-20-6977192. E-mail: c.wieland{at}amc.uva.nl

{triangledown} Published ahead of print on 30 July 2007.

Editor: J. N. Weiser

Infection and Immunity, October 2007, p. 5068-5072, Vol. 75, No. 10
0019-9567/07/$08.00+0     doi:10.1128/IAI.00287-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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