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Infection and Immunity, December 2007, p. 6008-6012, Vol. 75, No. 12
0019-9567/07/$08.00+0     doi:10.1128/IAI.01995-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The TolC-Like Protein of Neisseria meningitidis Is Required for Extracellular Production of the Repeats-in-Toxin Toxin FrpC but Not for Resistance to Antimicrobials Recognized by the Mtr Efflux Pump System{triangledown}

Nazia Kamal,1 Corinne Rouquette-Loughlin,1 and William M. Shafer1,2*

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322,1 Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia 300332

Received 20 December 2006/ Returned for modification 16 March 2007/ Accepted 26 September 2007

A 2.9-kilobase pair locus in Neisseria meningitidis was identified as containing transcriptionally linked open reading frames encoding TolC- and HlyD-like proteins. Although the meningococcal TolC protein was required for extracellular production of the repeats-in-toxin (RTX) FrpC toxin, it could not functionally replace the MtrE protein as the outer membrane protein channel for drug export by the MtrC-MtrD-MtrE efflux pump.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322. Phone: (404) 728-7688. Fax: (404) 329-2210. E-mail: wshafer{at}emory.edu

{triangledown} Published ahead of print on 8 October 2007.

Editor: V. J. DiRita

Infection and Immunity, December 2007, p. 6008-6012, Vol. 75, No. 12
0019-9567/07/$08.00+0     doi:10.1128/IAI.01995-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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