This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kamal, N.
Right arrow Articles by Shafer, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kamal, N.
Right arrow Articles by Shafer, W. M.

 Previous Article

Infection and Immunity, December 2007, p. 6008-6012, Vol. 75, No. 12
0019-9567/07/$08.00+0     doi:10.1128/IAI.01995-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The TolC-Like Protein of Neisseria meningitidis Is Required for Extracellular Production of the Repeats-in-Toxin Toxin FrpC but Not for Resistance to Antimicrobials Recognized by the Mtr Efflux Pump System{triangledown}

Nazia Kamal,1 Corinne Rouquette-Loughlin,1 and William M. Shafer1,2*

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322,1 Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia 300332

Received 20 December 2006/ Returned for modification 16 March 2007/ Accepted 26 September 2007

A 2.9-kilobase pair locus in Neisseria meningitidis was identified as containing transcriptionally linked open reading frames encoding TolC- and HlyD-like proteins. Although the meningococcal TolC protein was required for extracellular production of the repeats-in-toxin (RTX) FrpC toxin, it could not functionally replace the MtrE protein as the outer membrane protein channel for drug export by the MtrC-MtrD-MtrE efflux pump.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322. Phone: (404) 728-7688. Fax: (404) 329-2210. E-mail: wshafer{at}emory.edu

{triangledown} Published ahead of print on 8 October 2007.

Editor: V. J. DiRita

Infection and Immunity, December 2007, p. 6008-6012, Vol. 75, No. 12
0019-9567/07/$08.00+0     doi:10.1128/IAI.01995-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kamal, N., Shafer, W. M. (2010). Biologic Activities of the TolC-Like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli. Antimicrob. Agents Chemother. 54: 506-508 [Abstract] [Full Text]  
  • Sannigrahi, S., Zhang, X., Tzeng, Y.-L. (2009). Regulation of the type I protein secretion system by the MisR/MisS two-component system in Neisseria meningitidis. Microbiology 155: 1588-1601 [Abstract] [Full Text]  
  • Lewis, L. A., Choudhury, B., Balthazar, J. T., Martin, L. E., Ram, S., Rice, P. A., Stephens, D. S., Carlson, R., Shafer, W. M. (2009). Phosphoethanolamine Substitution of Lipid A and Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides and Complement-Mediated Killing by Normal Human Serum. Infect. Immun. 77: 1112-1120 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»