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Infection and Immunity, February 2007, p. 1034-1039, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01254-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Francisella tularensis Replicates within Alveolar Type II Epithelial Cells In Vitro and In Vivo following Inhalation{triangledown}

Joshua D. Hall, Robin R. Craven, James R. Fuller, Raymond J. Pickles, and Thomas H. Kawula*

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Received 5 August 2006/ Accepted 25 October 2006

Francisella tularensis replicates in macrophages and dendritic cells, but interactions with other cell types have not been well described. F. tularensis LVS invaded and replicated within alveolar epithelial cell lines. Following intranasal inoculation of C57BL/6 mice, Francisella localized to the alveolus and replicated within alveolar type II epithelial cells.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, CB#7290, University of North Carolina, Chapel Hill, NC 27599-7290. Phone: (919) 966-9699. Fax: (919) 962-8103. E-mail: Kawula{at}med.unc.edu.

{triangledown} Published ahead of print on 6 November 2006.

Editor: D. L. Burns

Infection and Immunity, February 2007, p. 1034-1039, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01254-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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