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Infection and Immunity, February 2007, p. 1040-1044, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01313-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Surface Proteins and Exotoxins Are Required for the Pathogenesis of Staphylococcus aureus Pneumonia{triangledown}

Juliane Bubeck Wardenburg,1,2 Ravi J. Patel,1 and Olaf Schneewind1*

Departments of Microbiology,1 Pediatrics, University of Chicago, Chicago, Illinois 606372

Received 14 August 2006/ Returned for modification 29 September 2006/ Accepted 2 November 2006

A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.

* Corresponding author. Mailing address: Department of Microbiology, University of Chicago, 920 E. 58th St., Chicago, IL 60637. Phone: (773) 834-9060. Fax: (773) 834-8150. E-mail: oschnee{at}bsd.uchicago.edu.

{triangledown} Published ahead of print on 13 November 2006.

Editor: V. J. DiRita

Infection and Immunity, February 2007, p. 1040-1044, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01313-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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