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Infection and Immunity, February 2007, p. 1040-1044, Vol. 75, No. 2
0019-9567/07/$08.00+0 doi:10.1128/IAI.01313-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Surface Proteins and Exotoxins Are Required for the Pathogenesis of Staphylococcus aureus Pneumonia
Juliane Bubeck Wardenburg,1,2
Ravi J. Patel,1 and
Olaf Schneewind1*
Departments of Microbiology,1
Pediatrics, University of Chicago, Chicago, Illinois 606372
Received 14 August 2006/
Returned for modification 29 September 2006/
Accepted 2 November 2006
A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.
* Corresponding author. Mailing address: Department of Microbiology, University of Chicago, 920 E. 58th St., Chicago, IL 60637. Phone: (773) 834-9060. Fax: (773) 834-8150. E-mail: oschnee{at}bsd.uchicago.edu.
Published ahead of print on 13 November 2006.
Editor: V. J. DiRita
Infection and Immunity, February 2007, p. 1040-1044, Vol. 75, No. 2
0019-9567/07/$08.00+0 doi:10.1128/IAI.01313-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
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Copyright © 2007 by the American Society for Microbiology. All rights reserved.