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Infection and Immunity, February 2007, p. 1045-1049, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01177-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Expression of Phosphorylcholine by Histophilus somni Induces Bovine Platelet Aggregation{triangledown}

Christopher J. Kuckleburg,1 Shaadi F. Elswaifi,2 Thomas J. Inzana,2 and Charles J. Czuprynski1*

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin,1 Center for Molecular Medicine and Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia2

Received 26 July 2006/ Returned for modification 13 September 2006/ Accepted 9 November 2006

Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP– H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.

* Corresponding author. Mailing address: Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Drive West, Madison, WI 53706. Phone and fax: (608) 262-8102. E-mail: czuprync{at}svm.vetmed.wisc.edu.

{triangledown} Published ahead of print on 21 November 2006.

Editor: J. N. Weiser

Infection and Immunity, February 2007, p. 1045-1049, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01177-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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