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Infection and Immunity, February 2007, p. 1050-1054, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01458-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Identification of the Gene Encoding the FhbB Protein of Treponema denticola, a Highly Unique Factor H-Like Protein 1 Binding Protein{triangledown}

John V. McDowell,1 Jesse Frederick,1 Lola Stamm,3 and Richard T. Marconi1,2*

Department of Microbiology and Immunology,1 Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298-0678,2 Department of Epidemiology, Infectious Diseases Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina3

Received 11 August 2006/ Returned for modification 29 September 2006/ Accepted 3 November 2006

The gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, and properties of FhbB were analyzed. The identification of FhbB represents an important step in understanding the contribution of FHL-1 binding in T. denticola pathogenesis and in development of periodontal disease.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, P.O. Box 980678, Richmond, VA 23298-0678. Phone: (804) 828-3779. Fax: (804) 828-9946. E-mail: rmarconi{at}hsc.vcu.edu.

{triangledown} Published ahead of print on 13 November 2006.

Editor: D. L. Burns

Infection and Immunity, February 2007, p. 1050-1054, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01458-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • McDowell, J. V., Huang, B., Fenno, J. C., Marconi, R. T. (2009). Analysis of a Unique Interaction between the Complement Regulatory Protein Factor H and the Periodontal Pathogen Treponema denticola. Infect. Immun. 77: 1417-1425 [Abstract] [Full Text]  
  • Frederick, J. R., Rogers, E. A., Marconi, R. T. (2008). Analysis of a Growth-Phase-Regulated Two-Component Regulatory System in the Periodontal Pathogen Treponema denticola. J. Bacteriol. 190: 6162-6169 [Abstract] [Full Text]  
  • Hovis, K. M., Freedman, J. C., Zhang, H., Forbes, J. L., Marconi, R. T. (2008). Identification of an Antiparallel Coiled-Coil/Loop Domain Required for Ligand Binding by the Borrelia hermsii FhbA Protein: Additional Evidence for the Role of FhbA in the Host-Pathogen Interaction. Infect. Immun. 76: 2113-2122 [Abstract] [Full Text]  
  • Rogers, E. A., Marconi, R. T. (2007). Delineation of Species-Specific Binding Properties of the CspZ Protein (BBH06) of Lyme Disease Spirochetes: Evidence for New Contributions to the Pathogenesis of Borrelia spp.. Infect. Immun. 75: 5272-5281 [Abstract] [Full Text]  


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