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Infection and Immunity, February 2007, p. 1055-1058, Vol. 75, No. 2
0019-9567/07/$08.00+0 doi:10.1128/IAI.00835-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain
E. Catherinot,1
J. Clarissou,2
G. Etienne,3
F. Ripoll,1
J.-F. Emile,4
M. Daffé,3
C. Perronne,2
C. Soudais,5
J.-L. Gaillard,1 and
M. Rottman1*
Laboratoire de Microbiologie,1
Département de Médecine Aiguë Spécialisée, Hôpital R. Poincaré (AP-HP) and Université de Versailles-Saint QuentinFaculté de Médecine Paris-Ile de France-Ouest, 92380 Garches,2
Institut de Pharmacologie et de Biologie Structurale du CNRSUMR 5089, Département "Mécanismes Moléculaires des Infections Mycobactériennes," 205 route de Narbonne, 31077 Toulouse Cedex,3
Laboratoire d'Anatomo-Pathologie, Hôpital A. Paré (AP-HP), 92100 Boulogne,4
Unité d'Immunologie et d'Hématologie, Hôpital Necker-Enfants Malades (AP-HP) and Laboratory of Human Genetics of Infectious Diseases, Université René DescartesINSERM U550, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15, France5
Received 24 May 2005/
Returned for modification 16 August 2006/
Accepted 30 November 2006
We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
* Corresponding author. Mailing address: Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré, 92380 Garches, France. Phone: 33.1.47.10.46.22. Fax: 33.1.47.10.79.49. E-mail: martin.rottman{at}rpc.aphp.fr.
Published ahead of print on 4 December 2006.
Editor: J. L. Flynn
Infection and Immunity, February 2007, p. 1055-1058, Vol. 75, No. 2
0019-9567/07/$08.00+0 doi:10.1128/IAI.00835-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
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Copyright © 2007 by the American Society for Microbiology. All rights reserved.