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Infection and Immunity, February 2007, p. 1059-1062, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01400-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge{triangledown}

Claudia Gianfaldoni, Stefano Censini, Markus Hilleringmann, Monica Moschioni, Claudia Facciotti, Werner Pansegrau, Vega Masignani, Antonello Covacci, Rino Rappuoli, Michèle Anne Barocchi,{dagger} and Paolo Ruggiero{dagger}*

Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy

Received 31 August 2006/ Returned for modification 21 October 2006/ Accepted 14 November 2006

Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.

* Corresponding author. Mailing address: Novartis Vaccines and Diagnostics s.r.l., Research Center, Via Fiorentina 1, I-53100 Siena, Italy. Phone: 39.0577.243111. Fax: 39.0577.243564. E-mail: paolo.ruggiero{at}novartis.com.

{triangledown} Published ahead of print on 4 December 2006.

Editor: A. Camilli

{dagger} M.A.B. and P.R. contributed equally to this work.

Infection and Immunity, February 2007, p. 1059-1062, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.01400-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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