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Infection and Immunity, March 2007, p. 1502-1506, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01801-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Selection for Simple Major Surface Protein 2 Variants during Anaplasma marginale Transmission to Immunologically Naïve Animals{triangledown}

Guy H. Palmer,1* James E. Futse,1 Christina K. Leverich,1 Donald P. Knowles Jr.,2 Fred R. Rurangirwa,1 and Kelly A. Brayton1

Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University,1 Animal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington2

Received 10 November 2006/ Returned for modification 1 December 2006/ Accepted 7 December 2006

Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.

* Corresponding author. Mailing address: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040. Phone: (509) 335-6033. Fax: (509) 335-8529. E-mail: gpalmer{at}vetmed.wsu.edu.

{triangledown} Published ahead of print on 18 December 2006.

Editor: R. P. Morrison

Infection and Immunity, March 2007, p. 1502-1506, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01801-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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