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Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin

Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840

Received 27 October 2006/ Returned for modification 14 November 2006/ Accepted 29 November 2006

We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.

Published ahead of print on 11 December 2006.

Editor: R. P. Morrison

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