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Infection and Immunity, March 2007, p. 1520-1523, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01316-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

c-Fos-Deficient Mice Are Susceptible to Salmonella enterica Serovar Typhimurium Infection{triangledown}

Kenta Maruyama, Gen-ichiro Sano, Neelanjan Ray, Yasunari Takada, and Koichi Matsuo*

Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Sinjuku-ku, 160-8582 Tokyo, Japan

Received 16 August 2006/ Returned for modification 2 October 2006/ Accepted 4 December 2006

c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-{kappa}B phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, School of Medicine, Keio University, 160-8582 Tokyo, Japan. Phone: 81-3-3353-1211. Fax: 81-3-5360-1508. E-mail: matsuo{at}sc.itc.keio.ac.jp.

{triangledown} Published ahead of print on 18 December 2006.

Editor: F. C. Fang

Infection and Immunity, March 2007, p. 1520-1523, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01316-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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