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Infection and Immunity, March 2007, p. 1524-1533, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01438-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

SiiE Is Secreted by the Salmonella enterica Serovar Typhimurium Pathogenicity Island 4-Encoded Secretion System and Contributes to Intestinal Colonization in Cattle{triangledown}

Eirwen Morgan,* Alison J. Bowen, Sonya C. Carnell, Timothy S. Wallis,{dagger} and Mark P. Stevens

Division of Microbiology, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom

Received 7 September 2006/ Returned for modification 16 October 2006/ Accepted 21 December 2006

Here we report that Salmonella enterica serovar Typhimurium pathogenicity island 4 carries a type I secretion system (siiCDF) which secretes an ~600-kDa protein (encoded by siiE). SiiE is surface expressed, and its production is regulated by HilA. SiiE and SiiF influence colonization in cattle and the invasion of bovine enterocytes.

* Corresponding author. Mailing address: Division of Microbiology, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom. Phone: 44 (0) 1635 578411. Fax: 44 (0) 1635 577237. E-mail: eirwen.morgan{at}bbsrc.ac.uk.

{triangledown} Published ahead of print on 12 January 2007.

Editor: J. B. Bliska

{dagger} Present address: Ridgeway Biologicals Ltd., c/o Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom.

Infection and Immunity, March 2007, p. 1524-1533, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01438-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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