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SiiE Is Secreted by the Salmonella enterica Serovar Typhimurium Pathogenicity Island 4-Encoded Secretion System and Contributes to Intestinal Colonization in Cattle

Eirwen Morgan,^* Alison J. Bowen, Sonya C. Carnell, Timothy S. Wallis, and Mark P. Stevens

Division of Microbiology, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom

Received 7 September 2006/ Returned for modification 16 October 2006/ Accepted 21 December 2006

Here we report that Salmonella enterica serovar Typhimurium pathogenicity island 4 carries a type I secretion system (siiCDF) which secretes an 600-kDa protein (encoded by siiE). SiiE is surface expressed, and its production is regulated by HilA. SiiE and SiiF influence colonization in cattle and the invasion of bovine enterocytes.

Published ahead of print on 12 January 2007.

Editor: J. B. Bliska

Present address: Ridgeway Biologicals Ltd., c/o Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom.

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