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Infection and Immunity, March 2007, p. 1537-1539, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01938-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Role of Unsaturated Fatty Acid Biosynthesis in Virulence of Streptococcus mutans{triangledown}

Elizabeth M. Fozo,1,{dagger} Kathy Scott-Anne,2 Hyun Koo,2,3 and Robert G. Quivey Jr.1,2*

Department of Microbiology and Immunology,1 Center for Oral Biology, Aab Institute for Biomedical Sciences,2 Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 146423

Received 8 December 2006/ Accepted 20 December 2006

An insertionally inactivated fabM strain of Streptococcus mutans does not produce unsaturated membrane fatty acids and is acid sensitive (E. M. Fozo and R. G. Quivey, Jr., J. Bacteriol. 186:4152-4158, 2004). In this study, the strain was shown to be poorly transmissible from host to host. Animals directly infected with the fabM strain exhibited fewer and less severe carious lesions than those observed in the wild-type strain.

* Corresponding author. Mailing address: Center for Oral Biology, Box 611, 601 Elmwood Avenue, Rochester, NY 14642. Phone: (585) 275-0382. Fax: (585) 276-0190. E-mail: Robert_Quivey{at}urmc.rochester.edu.

{triangledown} Published ahead of print on 12 January 2007.

Editor: V. J. DiRita

{dagger} Present address: National Institute for Child Health and Human Disease, National Institutes of Health, Bethesda, MD.

Infection and Immunity, March 2007, p. 1537-1539, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01938-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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