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Infection and Immunity, April 2007, p. 1577-1585, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01392-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Solitary Intestinal Lymphoid Tissue Provides a Productive Port of Entry for Salmonella enterica Serovar Typhimurium{triangledown}

Stephan Halle,1 Dirk Bumann,2 Heike Herbrand,1 Yvonne Willer,2 Sabrina Dähne,1 Reinhold Förster,1 and Oliver Pabst1*

Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany,1 Junior Research Group "Mucosal Infections," Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany2

Received 30 August 2006/ Returned for modification 20 November 2006/ Accepted 22 January 2007

Oral infection of mice with Salmonella enterica serovar Typhimurium results in the colonization of Peyer's patches, triggering a vigorous inflammatory response and immunopathology at these sites. Here we demonstrate that in parallel to Peyer's patches a strong inflammatory response occurs in the intestine, resulting in the appearance of numerous inflammatory foci in the intestinal mucosa. These foci surround small lymphoid cell clusters termed solitary intestinal lymphoid tissue (SILT). Salmonella can be observed inside SILT at early stages of infection, and the number of infected structures matches the number of inflammatory foci arising at later time points. Infection leads to enlargement and morphological destruction of SILT but does not trigger de novo formation of lymphoid tissue. In conclusion, SILT, a lymphoid compartment mostly neglected in earlier studies, represents a major site for Salmonella invasion and ensuing mucosal pathology.

* Corresponding author. Mailing address: Institute of Immunology, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany. Phone: 49-511-5329725. Fax: 49-511-5329722. E-mail: Pabst.Oliver{at}mh-hannover.de.

{triangledown} Published ahead of print on 5 February 2007.

Editor: F. C. Fang

Infection and Immunity, April 2007, p. 1577-1585, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01392-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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