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Infection and Immunity, April 2007, p. 2063-2066, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01565-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Putative Glycosyltransferase-Encoding Gene cylJ and the Group B Streptococcus (GBS)-Specific Gene cylK Modulate Hemolysin Production and Virulence of GBS{triangledown} ,{dagger}

Marie-Pierre Forquin,1 Asmae Tazi,2 Manuel Rosa-Fraile,3 Claire Poyart,2 Patrick Trieu-Cuot,1 and Shaynoor Dramsi1*

Unité de Biologie des Bactéries Pathogènes à Gram-Positif, Institut Pasteur, URA CNRS 2172, 25 Rue du Dr. Roux, 75724 Paris Cedex 15, France,1 INSERM 4567-umR CNRS 810, Institut Cochin, Université Paris Descartes, Paris, France,2 Microbiology Service, Virgen de las Nieves University Hospital, Granada, Spain3

Received 28 September 2006/ Returned for modification 3 December 2006/ Accepted 21 January 2007

Group B streptococcus (GBS) expresses a hemolysin/cytolysin that plays an important role in pathogenesis. Using the Himar1 transposon mutagenesis system, a hypohemolytic mutant carrying an interrupted cylJ gene was characterized. cylJ, encoding a putative glycosyltransferase, and cylK, whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS.

* Corresponding author. Mailing address: Unité de Biologie des Bactéries Pathogènes à Gram-Positif, Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 44 38 94 87. Fax: 33 1 45 68 89 38. E-mail: sdramsi{at}pasteur.fr.

{triangledown} Published ahead of print on 5 February 2007.

Editor: A. Camilli

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Infection and Immunity, April 2007, p. 2063-2066, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01565-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mistou, M.-Y., Dramsi, S., Brega, S., Poyart, C., Trieu-Cuot, P. (2009). Molecular Dissection of the secA2 Locus of Group B Streptococcus Reveals that Glycosylation of the Srr1 LPXTG Protein Is Required for Full Virulence. J. Bacteriol. 191: 4195-4206 [Abstract] [Full Text]  
  • Vanberg, C., Lutnaes, B. F., Langsrud, T., Nes, I. F., Holo, H. (2007). Propionibacterium jensenii Produces the Polyene Pigment Granadaene and Has Hemolytic Properties Similar to Those of Streptococcus agalactiae. Appl. Environ. Microbiol. 73: 5501-5506 [Abstract] [Full Text]  


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