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Infection and Immunity, April 2007, p. 2067-2070, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01727-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pneumolysin, PspA, and PspC Contribute to Pneumococcal Evasion of Early Innate Immune Responses during Bacteremia in Mice{triangledown}

Lisa R. Quin,1 Quincy C. Moore III,1 and Larry S. McDaniel1,2,3*

Departments of Microbiology,1 Surgery,2 Medicine, The University of Mississippi Medical Center, Jackson, Mississippi 392163

Received 27 October 2006/ Returned for modification 15 December 2006/ Accepted 4 January 2007

The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a {Delta}ply PspA– PspC– mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of {Delta}ply PspA– PspC– pneumococci compared to the clearance of nonencapsulated pneumococci.

* Corresponding author. Mailing address: Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216. Phone: (601) 984-6880. Fax: (601) 984-1708. E-mail: LMcDaniel{at}microbio.umsmed.edu.

{triangledown} Published ahead of print on 12 January 2007.

Editor: J. N. Weiser

Infection and Immunity, April 2007, p. 2067-2070, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01727-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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