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Infection and Immunity, April 2007, p. 2071-2074, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01785-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The rag Locus of Porphyromonas gingivalis Contributes to Virulence in a Murine Model of Soft Tissue Destruction{triangledown}

Xiaoju Shi,1 Shirley A. Hanley,1,# Marie-Claire Faray-Kele,1 Stuart C. Fawell,1 Joseph Aduse-Opoku,1 Robert A. Whiley,2 Michael A. Curtis,1 and Lucinda M. C. Hall1*

Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, London E1 2AT, United Kingdom,1 Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, London E1 2AT, United Kingdom2

Received 9 November 2006/ Returned for modification 17 December 2006/ Accepted 21 January 2007

The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.

* Corresponding author. Mailing address: Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom. Phone: 44 207882 2323. Fax: 44 207882 2181. E-mail: l.m.c.hall{at}qmul.ac.uk.

{triangledown} Published ahead of print on 5 February 2007.

Editor: A. Camilli

# Present address: Beckman Coulter Inc., Mervue Industrial Estate, Galway, Ireland.

Infection and Immunity, April 2007, p. 2071-2074, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01785-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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