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Infection and Immunity, April 2007, p. 2075-2078, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01920-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mice Lacking CD21 and CD35 Proteins Mount Effective Immune Responses against Borrelia burgdorferi Infection{triangledown}

Amanda C. Jacobson,1 Ying Ma,1 James F. Zachary,2 Janis J. Weis,1 and John H. Weis1*

Division of Cell Biology and Immunology, Department of Pathology, 15 North Medical Drive East, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650,1 Department of Veterinary Pathobiology, University of Illinois, Urbana, Illinois 618022

Received 5 December 2006/ Returned for modification 2 January 2007/ Accepted 25 January 2007

CD21/35–/– mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35–/– mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.

* Corresponding author. Mailing address: Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112-5650. Phone: (801) 581-7054. Fax: (801) 585-7376. E-mail: john.weis{at}path.utah.edu.

{triangledown} Published ahead of print on 5 February 2007.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2007, p. 2075-2078, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01920-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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